Héla Zakraoui, Samy Fenniche, Rym Benmously, Hajlaoui Khaoula, Hayet Marrak, Mohamed Ben Ayed, Inçaf Mokhtar
Service de dermatologie, Service d'anatomie-pathologique- Hôpital Habib Thameur de Tunis, Tunisie.
Tunis Med. 2005 Mar;83(3):154-6.
Lichen sclerosus is a chronic inflammatory mucocutaneous disease which origin remains unknown. Its prevalence ranges from one in 300 to one in 1000 of all patients referred to a dermatology clinic in the seventeenth. Through the analysis of a hospital survey, we outline the epidemio-clinical aspects of this dermatosis. Over a 19-year period (1984-2002), we have conducted a retrospective and monocentric study of all patients with genital lichen sclerosus were examined at the dermatology department of Habib Thameur hospital. Thirty-four patients suffered from lichen sclerosus. There were 33 female and only one male (sex-ratio: 0.03). All patients underwent topical corticosteroid therapy (level I, II or IV). The recovery rate of lichen sclerosus was about 20% (7/34). An epidermoid carcinoma occurred in three patients. The frequency of lichen sclerosus in our study is estimated at 1,8 new cases per year. This frequency is probably under-estimated because of some patients' reluctance to seek help. A relatively low recovery rate of genital lichen sclerosus was found in our study. This may be related to an inadequate follow up added to an insufficient treatment adherence.
硬化性苔藓是一种慢性炎症性黏膜皮肤疾病,其病因尚不清楚。在所有转诊至皮肤科诊所的患者中,其患病率在1/300至1/1000之间。通过对一项医院调查的分析,我们概述了这种皮肤病的流行病学临床特征。在19年期间(1984 - 2002年),我们对在哈比卜·塔穆尔医院皮肤科就诊的所有生殖器硬化性苔藓患者进行了一项回顾性单中心研究。34例患者患有硬化性苔藓。其中女性33例,男性仅1例(性别比:0.03)。所有患者均接受了局部皮质类固醇治疗(I级、II级或IV级)。硬化性苔藓的治愈率约为20%(7/34)。3例患者发生了表皮样癌。我们研究中硬化性苔藓的发病率估计为每年1.8例新发病例。由于一些患者不愿寻求帮助,这个发病率可能被低估了。在我们的研究中发现生殖器硬化性苔藓的治愈率相对较低。这可能与随访不足以及治疗依从性不够有关。