Simpkin Susan, Oakley Amanda
Health Waikato, Hamilton, New Zealand.
Australas J Dermatol. 2007 Feb;48(1):28-31. doi: 10.1111/j.1440-0960.2007.00322.x.
Two hundred and two patients with clinically typical or biopsy-confirmed vulval lichen sclerosus were reviewed either at consultation (75%) or by retrospectively examining their chart. At diagnosis, 79% were 50 years or older. Ninety-six per cent complained of itching, pain and/or dyspareunia. Lichen sclerosus most often affected the labia minora and perineum but 50% had perianal and 13% had extragenital disease. Thirty-five patients gave a history of psoriasis (17%), which affected the vulval area in 10. Thyroid disease was reported in 39 patients (19%), and 33 gave a family history of thyroid disease. Of those tested (142), 20% had elevated thyroid antibodies. Topical clobetasol propionate was very effective but at least intermittent treatment was required long term in 85%. At follow up, 101 of 185 patients (56%) were asymptomatic but 22 (12%) continued to have moderate-to-severe symptoms. Thyroid disease and psoriasis are common associated conditions.
对202例临床症状典型或活检确诊为外阴硬化性苔藓的患者进行了回顾性研究，其中75%的患者在会诊时进行了评估，其余患者则通过查阅病历进行回顾性分析。诊断时，79%的患者年龄在50岁及以上。96%的患者主诉有瘙痒、疼痛和/或性交困难。硬化性苔藓最常累及小阴唇和会阴，但50%的患者有肛周病变，13%的患者有生殖器外病变。35例患者有银屑病病史（17%），其中10例累及外阴部。39例患者（19%）报告有甲状腺疾病，33例有甲状腺疾病家族史。在接受检测的142例患者中，20%的患者甲状腺抗体升高。外用丙酸氯倍他索非常有效，但85%的患者至少需要长期间歇性治疗。随访时，185例患者中有101例（56%）无症状，但22例（12%）仍有中度至重度症状。甲状腺疾病和银屑病是常见的相关疾病。
