Park C W, Lee B H, Lee C H
Department of Dermatology, College of Medicine, Hallym University, Seoul, Korea.
Drugs Exp Clin Res. 2005;31(2):77-87.
It is well known that topical tacrolimus is safe and effective in the treatment of atopic dermatitis (AD) patients. Tacrolimus is primarily an immunosuppressive agent without any antistaphylococcal effects. Thus colonization of Staphylococcus aureus on the skin of patients treated with this agent might be increased. The purpose of this study was to determine the effect of tacrolimus on S. aureus colonization in patients with AD and to compare the results with clinical severity and skin barrier function. We enrolled 65 patients with moderate to severe AD. They were treated with 0.03% tacrolimus ointment twice daily for 4 weeks. Clinical severity was assessed by the eczema area and severity index (EASI). S. aureus colonization was measured by the tape method. Skin barrier function was checked by measuring transepidermal water loss (TEWL). Evaluations were performed at weeks 0 (baseline), 1, 2 and 4. The results were compared and statistical analysis was performed. S. aureus colonization was significantly decreased with tacrolimus treatment at week 1 compared with baseline. However, there were no differences among weeks 1, 2 and 4. EASI and TEWL showed a decreasing tendency in a time-dependent fashion. The correlations between data were variable.
众所周知，局部使用他克莫司治疗特应性皮炎（AD）患者是安全有效的。他克莫司主要是一种免疫抑制剂，没有任何抗葡萄球菌的作用。因此，使用该药物治疗的患者皮肤上金黄色葡萄球菌的定植可能会增加。本研究的目的是确定他克莫司对AD患者金黄色葡萄球菌定植的影响，并将结果与临床严重程度和皮肤屏障功能进行比较。我们招募了65例中度至重度AD患者。他们每天两次外用0.03%他克莫司软膏，持续4周。通过湿疹面积和严重程度指数（EASI）评估临床严重程度。通过胶带法测量金黄色葡萄球菌定植情况。通过测量经表皮水分流失（TEWL）来检查皮肤屏障功能。在第0周（基线）、第1周、第2周和第4周进行评估。对结果进行比较并进行统计分析。与基线相比，第1周使用他克莫司治疗后金黄色葡萄球菌定植显著减少。然而，第1周、第2周和第4周之间没有差异。EASI和TEWL呈时间依赖性下降趋势。数据之间的相关性各不相同。
