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孕期甲状腺抗体的系列研究。

Sequential studies on thyroid antibodies during pregnancy.

作者信息

Smyth P P A, Wijeyaratne C N, Kaluarachi W N, Smith D F, Premawardhana L D K E, Parkes A B, Jayasinghe A, de Silva D G H, Lazarus J H

机构信息

Endocrine Laboratory, Department of Medicine and Therapeutics, Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland.

出版信息

Thyroid. 2005 May;15(5):474-7. doi: 10.1089/thy.2005.15.474.

Abstract

Thyroid antibodies were measured sequentially in 25 pregnant women from a Sri Lankan population. A high prevalence of antithyroid antibodies, particularly antithyroglobulin antibodies (TgAb) had previously been demonstrated in female schoolchildren drawn from this population. In the present study TgAb were detected in 36.8% of nonpregnant controls while thyroid peroxidase antibody (TPOAb) positivity was present in 26.3%. The prevalence of both antibodies in the pregnancy study group showed a progressive decline compared to nonpregnant controls throughout gestation becoming undetectable in the third trimester. The results are consistent with an immunosuppressive effect of pregnancy in a population in whom high thyroid autoantibody titers may have resulted from a recent salt iodization program.

摘要

对来自斯里兰卡人群的25名孕妇进行了甲状腺抗体的连续检测。此前已证明,从该人群中抽取的女学生抗甲状腺抗体,尤其是抗甲状腺球蛋白抗体(TgAb)的患病率很高。在本研究中,36.8%的非孕对照组检测到TgAb,而甲状腺过氧化物酶抗体(TPOAb)阳性率为26.3%。与非孕对照组相比,妊娠研究组中这两种抗体的患病率在整个妊娠期呈逐渐下降趋势,在妊娠晚期无法检测到。这些结果与妊娠的免疫抑制作用一致,在该人群中,高甲状腺自身抗体滴度可能是近期食盐碘化计划导致的。

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