Yan Yue-Rong, Gao Xi-Lian, Zeng Jing, Liu Yang, Lv Qing-Guo, Jiang Jing, Huang Hui, Tong Nan-Wei
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Yulin Community Health Service Centre, Chengdu, Sichuan Province, China.
J Int Med Res. 2015 Jun;43(3):412-23. doi: 10.1177/0300060514562487. Epub 2015 Apr 8.
To evaluate the association between thyroid autoantibodies and abnormalities in thyroid function and structure, and to investigate any risk factors.
A cross-sectional survey was undertaken in Chengdu residents ≥ 18 years with no previous thyroid disease. The study participants provided demographic and clinical data. Thyroid function and serum concentrations of the thyroid autoantibodies antithyroperoxidase antibody (TPOAb) and antithyroglobulin antibody (TgAb) were measured.
A total of 1334 subjects were included in this study. The prevalence of TPOAb and TgAb positivity was significantly higher in female than in male subjects. The prevalence of thyroid autoantibodies in those with subclinical hypothyroidism and clinical hyper- and hypothyroidism was significantly greater than in euthyroid subjects. The concentration of TPOAb and TgAb in subjects with both TPOAb and TgAb was significantly higher than in those who exhibited only one type of thyroid autoantibody. Using multivariate logistic regression analysis, female sex, thyroid volume, thyroid hypo- and heteroechogenicity were found to be risk factors for the presence of autoantibodies.
Thyroid autoantibodies were common in the general population. Women with thyroid enlargement, hypoechogenicity and heteroechogenicity might benefit from routine screening for thyroid autoantibodies and thyroid function.
评估甲状腺自身抗体与甲状腺功能及结构异常之间的关联，并调查相关危险因素。
对成都18岁及以上无甲状腺疾病史的居民进行横断面调查。研究参与者提供人口统计学和临床数据。检测甲状腺功能以及甲状腺自身抗体抗甲状腺过氧化物酶抗体（TPOAb）和抗甲状腺球蛋白抗体（TgAb）的血清浓度。
本研究共纳入1334名受试者。女性受试者中TPOAb和TgAb阳性率显著高于男性。亚临床甲状腺功能减退症、临床甲状腺功能亢进症和甲状腺功能减退症患者中甲状腺自身抗体的患病率显著高于甲状腺功能正常的受试者。同时存在TPOAb和TgAb的受试者中TPOAb和TgAb的浓度显著高于仅表现出一种甲状腺自身抗体的受试者。采用多因素logistic回归分析，发现女性、甲状腺体积、甲状腺回声减低和不均匀回声是自身抗体存在的危险因素。
甲状腺自身抗体在普通人群中很常见。甲状腺肿大、回声减低和不均匀回声的女性可能受益于甲状腺自身抗体和甲状腺功能的常规筛查。
