Errico Thomas J
Department of Orthopedic Surgery, New York University Hospital for Joint Diseases, 530 First Avenue, New York, NY 10016, USA.
Clin Orthop Relat Res. 2005 Jun(435):106-17. doi: 10.1097/01.blo.0000165718.22159.d9.
Degenerative disc disease is the leading cause of pain and disability in adults in North America, and spinal fusion is the standard treatment. Despite this, it has been discussed among surgeons that (1) spinal fusion deserves reexamination in terms of its long-term consequences and benefits and (2) modern clinical research and development in disc arthroplasty strongly supports its emergence as an alternative. The ability to relieve pain by maintaining motion may be a critical factor in obtaining not only greater pain relief but in preventing adjacent segment degeneration. Early research in arthroplasty devices was promising but cut short. New knowledge in the functional anatomy and biomechanics of the spine has made possible the development of modern arthroplasty devices (eg, Charite Artificial Disc, ProDisc, Maverick device, FlexiCore device) of different constructions and materials (metal-on-plastic, metal-on-metal) and various ranges of motion/mobility that provide a basis for a classification of spinal mode and an assistance in implant selection. Current research also is confronting the critical obstacles of wear and tear and axial compression. Several devices currently are in clinical trials. A detailed review of their characteristics shows the exciting progress of a new treatment era of total disc replacement in spine-lumbar disc arthroplasty.
退行性椎间盘疾病是北美成年人疼痛和残疾的主要原因,脊柱融合术是标准治疗方法。尽管如此,外科医生们一直在讨论:(1)脊柱融合术在长期后果和益处方面值得重新审视;(2)椎间盘置换术的现代临床研究与开发有力地支持了其作为一种替代疗法的出现。通过维持活动来缓解疼痛的能力可能不仅是实现更大程度疼痛缓解的关键因素,也是预防相邻节段退变的关键因素。早期关于置换装置的研究很有前景,但却中断了。脊柱功能解剖学和生物力学方面的新知识使得开发不同结构和材料(金属对塑料、金属对金属)以及各种活动范围的现代置换装置(如Charite人工椎间盘、ProDisc、Maverick装置、FlexiCore装置)成为可能,这些装置为脊柱模式分类和植入物选择提供了依据。当前的研究也面临着磨损和轴向压缩等关键障碍。目前有几种装置正在进行临床试验。对其特性的详细综述显示了脊柱腰椎间盘置换术这一全新治疗时代令人振奋的进展。