多囊卵巢综合征中的月经周期不规律与甾体激素
Irregular cycles and steroid hormones in polycystic ovary syndrome.
作者信息
Doi Suhail A R, Al-Zaid Mona, Towers Philip A, Scott Christopher J, Al-Shoumer Kamal A S
机构信息
Division of Endocrinology, Mubarak Al-Kabeer Hospital and Department of Medicine, Faculty of Medicine, Kuwait University.
出版信息
Hum Reprod. 2005 Sep;20(9):2402-8. doi: 10.1093/humrep/dei093. Epub 2005 Jun 2.
BACKGROUND
This cross-sectional study was undertaken to evaluate the factors that relate to menstrual status (oligo-amenorrhoea versus eumenorrhoea) in polycystic ovary syndrome (PCOS).
METHODS
A total of 234 women with clinical and biochemical features suggestive of PCOS underwent metabolic and hormonal evaluation. A forward stepwise logistic regression model was created based on the results to determine variables related to ovulatory status.
RESULTS
Only follicular phase progesterone and estradiol (E(2)) were retained in the final model. This model correctly classified 80% of PCOS women by ovulatory status. Univariate analysis revealed no difference in progesterone between ovulatory groups but E(2) was higher in anovulatory groups. This suggested interaction between progesterone and E(2) and the single interaction variable (progesterone/E(2)) also classified 80% of women by ovulatory status correctly.
CONCLUSION
The results suggest that a low ratio of progesterone to E(2) is associated with menstrual irregularity and ovulatory status in PCOS.
背景
本横断面研究旨在评估多囊卵巢综合征（PCOS）中与月经状态（月经过少/闭经与正常月经）相关的因素。
方法
共有234名具有PCOS临床和生化特征的女性接受了代谢和激素评估。根据结果建立向前逐步逻辑回归模型，以确定与排卵状态相关的变量。
结果
最终模型中仅保留了卵泡期孕酮和雌二醇（E₂）。该模型根据排卵状态正确分类了80%的PCOS女性。单因素分析显示排卵组之间孕酮无差异，但无排卵组的E₂较高。这表明孕酮与E₂之间存在相互作用，单一相互作用变量（孕酮/E₂）也能根据排卵状态正确分类80%的女性。
结论
结果表明，PCOS中孕酮与E₂的低比值与月经不规律和排卵状态相关。
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