Myburgh J A, Chapman M J, Szekely S M, Osborne G A
University of New South Wales, Director of Research, Department of Intensive Care Medicine, The St. George Hospital, Sydney, Australia.
Qual Saf Health Care. 2005 Jun;14(3):e22. doi: 10.1136/qshc.2002.004234.
Anaesthesia with concurrent sepsis is risky, and involves consideration of possible organ dysfunctions-respiratory, cardiovascular, renal, and haematological--as well as ensuring that appropriate antibiotics are given after taking the necessary microbiological specimens. Because prompt attention needs to be paid to so many body systems, the place for a structured approach during anaesthesia for a septic patient was assessed.
To examine the role of a previously described core algorithm "COVER ABCD-A SWIFT CHECK", supplemented by a specific sub-algorithm for sepsis, in the management of sepsis occurring in association with anaesthesia.
The potential performance of this structured approach for each of the relevant incidents among the first 4000 reported to the Australian Incident Monitoring Study (AIMS) was compared with the actual management as reported by the anaesthetists involved.
Sepsis was identified as the primary problem in 13 of the first 4000 reports (<1%) to AIMS. The incidents reported generally occurred in sick patients; 70% were ASA status III or worse. The COVER ABCD algorithm provided a diagnosis and corrective manoeuvre in only 15% (2/13) of reported incidents, and the sepsis sub-algorithm provided adequate therapeutic strategies in a further 38% (5/13) of the incidents. Eight cases required the use of additional sub-algorithms for desaturation (30%), cardiac arrest (15%), hypotension (8%), and aspiration (8%).
Sepsis involves a serious physiological stress upon multiple organ systems. The use of a structured approach involving a core algorithm and additional sub-algorithms as required provides a series of checklists that can successfully deal with the complex multiple and interrelating problems that these patients present.
同时患有败血症时进行麻醉具有风险,需要考虑可能出现的器官功能障碍,包括呼吸、心血管、肾脏和血液系统等方面,同时要确保在采集必要的微生物标本后给予适当的抗生素。由于需要对众多身体系统迅速予以关注,因此对在败血症患者麻醉期间采用结构化方法的场所进行了评估。
研究先前描述的核心算法“COVER ABCD - A SWIFT CHECK”(辅以败血症特定子算法)在与麻醉相关的败血症管理中的作用。
将这种结构化方法针对向澳大利亚事件监测研究(AIMS)报告的前4000起相关事件中每起事件的潜在表现,与参与的麻醉师报告的实际管理情况进行比较。
在向AIMS报告的前4000份报告中,有13份(<1%)将败血症确定为主要问题。报告的事件通常发生在病情严重的患者中;70%为ASA状态III级或更差。COVER ABCD算法仅在15%(2/13)的报告事件中提供了诊断和纠正措施,败血症子算法在另外38%(5/13)的事件中提供了适当的治疗策略。8例需要使用针对低氧血症(30%)、心脏骤停(15%)、低血压(8%)和误吸(8%)的额外子算法。
败血症会对多个器官系统造成严重的生理应激。采用涉及核心算法并根据需要使用额外子算法的结构化方法,提供了一系列检查表,能够成功应对这些患者所呈现的复杂多样且相互关联的问题。