Chang Christopher Y, Schell Wiley A, Perfect John R, Hulka Gregory F
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
Laryngoscope. 2005 Jun;115(6):1065-9. doi: 10.1097/01.MLG.0000163338.45700.FE.
To describe an extremely rare fungal mastoiditis caused by Lecythophora hoffmannii, its recalcitrant behavior to therapy, and eventual successful treatment with adjunctive therapy using polyhexamethylene biguanide (a common swimming pool biocide).
Case report and review of literature of human Lecythophora hoffmannii infections.
Medline database was searched using the keywords Lecythophora and hoffmannii. All articles that described Lecythophora hoffmannii as the cause of human infection at any site were identified. Literature and patient's records were considered for complete data review and extraction.
We present the second known case in the literature of a human infection with Lecythophora hoffmannii. We also present the process to definitively identify and then to successfully eradicate this unusual fungal infection using polyhexamethylene biguanide as adjunctive treatment.
Successful treatment of a chronic Lecythophora hoffmannii fungal mastoiditis involved a combination of radical surgical removal of all apparent infected tissue along with local treatments with polyhexamethylene biguanide, a common swimming pool biocide agent under the brand name Baquacil (Avecia, Manchester, United Kingdom). Given the prolonged course of treatment, this report particularly stresses the importance of concurrent surgery combined with creative local antimicrobial therapy to eliminate an unusual fungal infection in an immunocompetent host.
描述由霍夫曼勒氏瓶霉引起的一种极其罕见的真菌性乳突炎、其对治疗的顽固反应，以及最终使用聚六亚甲基双胍（一种常见的游泳池杀菌剂）辅助治疗成功治愈的情况。
人类霍夫曼勒氏瓶霉感染的病例报告及文献综述。
使用关键词“勒氏瓶霉”和“霍夫曼”检索Medline数据库。识别所有将霍夫曼勒氏瓶霉描述为人类任何部位感染病因的文章。查阅文献和患者记录以进行完整的数据审查和提取。
我们报告了文献中第二例已知的人类感染霍夫曼勒氏瓶霉的病例。我们还展示了明确识别并随后使用聚六亚甲基双胍作为辅助治疗成功根除这种罕见真菌感染的过程。
成功治疗慢性霍夫曼勒氏瓶霉真菌性乳突炎需要彻底手术切除所有明显感染组织，并结合使用聚六亚甲基双胍进行局部治疗，聚六亚甲基双胍是一种常见的游泳池杀菌剂，商品名为百可适（Avecia公司，英国曼彻斯特）。鉴于治疗过程漫长，本报告特别强调了在免疫功能正常的宿主中，联合手术与创新的局部抗菌治疗对于消除罕见真菌感染的重要性。
