CYFRA21-1与TSGF联合检测在鼻咽癌中的诊断价值
[Diagnostic value of combined detection of CYFRA21-1 and TSGF in nasopharyngeal carcinoma].
作者信息
Huang Lingsha, Huang Wencheng, Chen Yanhua
机构信息
Affiliated Cancer Hospital of Guangxi Medical University, Nanning, 530021, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Mar;19(5):201-2.
OBJECTIVE
To study the diagnostic value of cytokeraetin 19 fragment (CYFRA21-1) and tumor supplied group factors (TSGF) in nasopharyngeal carcinoma (NPC).
METHOD
Serum levels of CYFRA21-1 and TSGF in 82 patients with NPC, 25 patients with benign nasopharyngeal disease and 50 normal controls were measured by electrochemiluminescence immuno-assay.
RESULT
The levels of CYFRA21-1 and TSGF in NPC group were remarkably higher than those in benign nasopharyngeal disease and normal control groups (P < 0.01). Sensitivities of CYFRA21-1 and TSGF were 48.8% and 57.3%, respectively. The sensitivity of combined detection of two tumor markers increased to 74.3% and the specificity was not decreased significantly.
CONCLUSION
CYFRA21-1 and TSGF can serve as the serum tumor marker in clinical diagnosis of NPC. Combined detection of two kinds of serum tumor markers increases the detective positive rate.
目的
探讨细胞角蛋白19片段（CYFRA21-1）和肿瘤相关物质群（TSGF）在鼻咽癌（NPC）诊断中的价值。
方法
采用电化学发光免疫分析法检测82例鼻咽癌患者、25例鼻咽良性疾病患者及50例正常对照者血清中CYFRA21-1和TSGF水平。
结果
鼻咽癌组CYFRA21-1和TSGF水平显著高于鼻咽良性疾病组和正常对照组（P<0.01）。CYFRA21-1和TSGF的灵敏度分别为48.8%和57.3%。两种肿瘤标志物联合检测的灵敏度提高至74.3%，特异性无明显下降。
结论
CYFRA21-1和TSGF可作为鼻咽癌临床诊断的血清肿瘤标志物。两种血清肿瘤标志物联合检测可提高检测阳性率。
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