Wurm Peter, De Caestecker John
Digestive Diseases Centre, University Hospitals of Leicester, Leicester, UK.
Expert Opin Emerg Drugs. 2005 May;10(2):457-71. doi: 10.1517/14728214.10.2.457.
Gastro-oesophageal reflux disease is a common medical problem caused by the exposure of the distal oesophagus to gastric contents. Existing medical therapy is very effective, but symptomatic relief with acid suppressants is often delayed. Treatment focuses on the suppression of gastric acid rather than on the underlying pathophysiological abnormalities, such as transient non-swallow-related lower oesophageal sphincter relaxation. Current pharmacological developments concentrate on drugs with lasting acid suppression and a faster onset of action. Compounds interacting with the complex neuromuscular regulation of the gastro-oesophageal junction are also being developed and offer exciting prospects.
胃食管反流病是一种常见的医学问题，由远端食管暴露于胃内容物引起。现有的药物治疗非常有效，但使用抑酸剂缓解症状往往会延迟。治疗重点在于抑制胃酸，而非潜在的病理生理异常，如与吞咽无关的短暂性食管下括约肌松弛。目前的药理学进展集中在具有持久抑酸作用和更快起效的药物上。与胃食管交界处复杂神经肌肉调节相互作用的化合物也在研发中，前景令人振奋。
