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产前暴露于甲基苯丙胺的成年雄性和雌性大鼠对氟代乙酰胺诱发癫痫的易感性增加。

Flurothyl seizures susceptibility is increased in prenatally methamphetamine-exposed adult male and female rats.

作者信息

Slamberová R

机构信息

Departments of Normal, Pathological and Clinical Physiology, 3rd Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00 Praha 2, Prague, Czech Republic.

出版信息

Epilepsy Res. 2005 Jun;65(1-2):121-4. doi: 10.1016/j.eplepsyres.2005.04.002.

DOI:10.1016/j.eplepsyres.2005.04.002
PMID:15935622
Abstract

The purpose of the present study was to examine the effect of prenatal methamphetamine (MA) exposure on flurothyl seizures. Adult prenatally MA-exposed male rats had decreased threshold of the first fasciculation and clonic seizure. In adult female rats, prenatal MA exposure decreased the threshold of the first fascicualtion in diestrous females, while there were no changes in proestrous or estrous females. The tonic-clonic seizure threshold was not altered by prenatal MA exposure.

摘要

本研究的目的是检测产前暴露于甲基苯丙胺（MA）对氟烷惊厥的影响。成年期产前暴露于MA的雄性大鼠首次肌束颤动和阵挛性惊厥的阈值降低。在成年雌性大鼠中，产前暴露于MA降低了处于间情期雌性大鼠首次肌束颤动的阈值，而在动情前期或发情期的雌性大鼠中则没有变化。产前暴露于MA并未改变强直阵挛性惊厥阈值。

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Flurothyl seizures susceptibility is increased in prenatally methamphetamine-exposed adult male and female rats.产前暴露于甲基苯丙胺的成年雄性和雌性大鼠对氟代乙酰胺诱发癫痫的易感性增加。
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引用本文的文献

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Sci Rep. 2018 Jan 30;8(1):1845. doi: 10.1038/s41598-018-20288-2.
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Effects of a single postnatal methamphetamine administration on NMDA-induced seizures are sex- and prenatal exposure-specific.产后单次给予甲基苯丙胺对N-甲基-D-天冬氨酸（NMDA）诱导的癫痫发作的影响具有性别和产前暴露特异性。
Naunyn Schmiedebergs Arch Pharmacol. 2009 Aug;380(2):109-14. doi: 10.1007/s00210-009-0427-7. Epub 2009 May 14.