Pejovic M, Stankovic A, Mitrovic D R
Institute for Rheumatology and Medical School, Niska Banja, University of Nis, Yugoslavia.
J Rheumatol. 1992 Apr;19(4):529-33.
By determining the total activity of total lactate dehydrogenase (LDH-T) and its isoenzymes in serum and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and osteo-arthritis (OA) we demonstrated in RA serum increased (p less than 0.02) activity of hepatic LDH (LDH-H) and a shift of the LDH isoenzymatic profile towards the M forms; in rheumatoid SF increased (p less than 0.001) activity of the total LDH-T and LDH-H which makes possible the use of these markers of inflammation in assessing RA activity. Values for LDH-T and LDH-H of 400-700 U/l and 300-500 U/l, respectively, correspond to moderate disease activity, while values exceeding 750 U/l and 550 U/l, respectively, correspond to high RA activity. The anaerobic isoenzymatic distribution of LDH in rheumatoid SF results in a significant (p less than 0.001) decrease in LDH1 and LDH2 and an increase (p less than 0.001) in LDH4 and LDH5.
通过测定类风湿性关节炎（RA）和骨关节炎（OA）患者血清及滑液（SF）中总乳酸脱氢酶（LDH-T）及其同工酶的总活性，我们发现，在RA患者血清中，肝脏型乳酸脱氢酶（LDH-H）活性升高（p<0.02），且乳酸脱氢酶同工酶谱向M型转变；在类风湿性滑液中，总LDH-T和LDH-H活性升高（p<0.001），这使得这些炎症标志物可用于评估RA的活动度。LDH-T和LDH-H的值分别为400 - 700 U/l和300 - 500 U/l时，对应中等疾病活动度，而分别超过750 U/l和550 U/l时，则对应较高的RA活动度。类风湿性滑液中乳酸脱氢酶的无氧同工酶分布导致LDH1和LDH2显著降低（p<0.001），而LDH4和LDH5升高（p<0.001）。
