保加利亚接触苯的石化工人的接触和效应生物标志物。
Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene.
作者信息
Garte Seymour, Popov Todor, Georgieva Tzveta, Bolognesi Claudia, Taioli Emanuela, Bertazzi Pieralberto, Farmer Peter, Merlo Domenico Franco
机构信息
School of Public Health, UMDNJ, 330 George St., New Brunswick, NJ 08903, USA.
出版信息
Chem Biol Interact. 2005 May 30;153-154:247-51. doi: 10.1016/j.cbi.2005.03.030.
Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene.
在158名保加利亚石化工人和50名匹配的对照者中评估了苯暴露及其影响的生物标志物。工人的空气中苯暴露平均约为1.8 ppm，对照者为0.02 ppm。尿中反式、反式粘康酸和S-苯基粘康酸与苯的空气暴露呈剂量反应关系。DNA单链断裂（SSB）的剂量反应曲线显示出饱和效应，而代谢物的剂量反应曲线则未显示。NQO1基因型对SSB有显著影响。我们得出结论，这些代谢物的途径可能与苯诱导的某些形式的遗传毒性损伤所涉及的途径不同。
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