Ishimori Takayoshi, Tatsumi Mitsuaki, Wahl Richard L
Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, 601 N Caroline Street, Room 3223A, Baltimore, MD 21287, USA.
Acad Radiol. 2005 Jun;12(6):776-81. doi: 10.1016/j.acra.2005.03.062.
Measurements of tumor size are important in assessing response to cancer therapies. To date, preclinical studies of drug development have relied on direct caliper-based measurements of tumor size. We investigated the feasibility of using a human positron emission tomographic (PET)/computed tomographic (CT) scanner to assess tumor size before and after chemotherapy and compared this approach with caliper measurements.
Fourteen rats with rat mammary tumor underwent high-resolution CT using a PET/CT scanner before and after chemotherapy, and tumor volumes were measured independently by two observers using calipers and CT images.
Tumor response could be detected after 1 day of treatment by means of CT imaging, but was not significant until 2 days or later by means of caliper measures because of their greater variability. Independent measurements of tumor size correlated well with one another by means of CT, but correlated less by means of calipers.
Tumor size measurements by means of CT from PET/CT were more reliable than caliper measurements because of their smaller variance, allowing earlier assessment of response. It is suggested that CT imaging-based methods of assessing tumor response replace traditional caliper-based measurements, much as CT has become a standard for assessing tumor response in humans.
肿瘤大小的测量对于评估癌症治疗反应至关重要。迄今为止，药物研发的临床前研究一直依赖基于卡尺的肿瘤大小直接测量。我们研究了使用人类正电子发射断层扫描（PET）/计算机断层扫描（CT）扫描仪评估化疗前后肿瘤大小的可行性，并将这种方法与卡尺测量进行了比较。
14只患有大鼠乳腺肿瘤的大鼠在化疗前后使用PET/CT扫描仪进行高分辨率CT检查，两名观察者分别使用卡尺和CT图像独立测量肿瘤体积。
通过CT成像在治疗1天后即可检测到肿瘤反应，但由于卡尺测量的变异性较大，直到2天或更晚时才显示出显著差异。通过CT进行的肿瘤大小独立测量彼此之间相关性良好，但通过卡尺测量的相关性较差。
由于PET/CT的CT测量方差较小，因此比卡尺测量更可靠，能够更早地评估反应。建议基于CT成像的肿瘤反应评估方法取代传统的基于卡尺的测量方法，就像CT已成为评估人类肿瘤反应的标准一样。
