源自沙利度胺的细胞分化诱导剂。
Cell differentiation inducers derived from thalidomide.
作者信息
Noguchi Tomomi, Miyachi Hiroyuki, Katayama Ryohei, Naito Mikihiko, Hashimoto Yuichi
机构信息
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
出版信息
Bioorg Med Chem Lett. 2005 Jul 1;15(13):3212-5. doi: 10.1016/j.bmcl.2005.05.005.
PMID:15936192
Abstract
5-Hydroxy- and 4-amino-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33 and 4APP-33, respectively) have been shown to possess cell differentiation-inducing activity toward human leukemia cell line HL-60.
摘要
5-羟基-4-氨基-2-(2,6-二异丙基苯基)-1H-异吲哚-1,3-二酮（分别为5HPP-33和4APP-33）已被证明对人白血病细胞系HL-60具有诱导细胞分化的活性。
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