Yoo Seung-Schik, O'leary Heather M, Dickey Chandlee C, Wei Xing Chang, Guttmann Charles R G, Park Hyun Wook, Panych Lawrence P
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Neurosci Lett. 2005;383(1-2):1-6. doi: 10.1016/j.neulet.2005.03.025. Epub 2005 Apr 13.
The leftward hemispheric dominance in language processing may be associated with fundamental functional asymmetry in the primary auditory cortex (PAC). Based on repeated functional MRI (fMRI) measurements, we investigated the presence of functional asymmetry in the human PAC using binaural presentation of linguistic sounds (two-syllable nouns) and simple tonal stimulation. Eight right-handed volunteers underwent nine fMRI sessions, approximately eight weeks apart, spanning the duration of more than a year. The PAC from each hemisphere was manually segmented and the volume of activation, detected within the segmented region-of-interest, was measured across the subjects and sessions to generate functional laterality indices. Although variations existed in activation volume between sessions and subjects, we found predominant and consistent leftward functional asymmetry in PAC during both linguistic and non-linguistic sound stimulations.
语言处理过程中大脑半球左侧优势可能与初级听觉皮层（PAC）的基本功能不对称有关。基于重复功能磁共振成像（fMRI）测量，我们使用语言声音（双音节名词）的双耳呈现和简单音调刺激来研究人类PAC中功能不对称的存在情况。八名右利手志愿者接受了九次fMRI检查，每次检查间隔约八周，持续时间超过一年。对每个半球的PAC进行手动分割，并测量在分割的感兴趣区域内检测到的激活体积，以生成功能偏侧性指数，该指数在所有受试者和检查中进行测量。尽管不同检查和受试者之间的激活体积存在差异，但我们发现在语言和非语言声音刺激期间，PAC中均存在主要且一致的左侧功能不对称。
