Unniappan Suraj, Peter Richard E
Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9.
Comp Biochem Physiol A Mol Integr Physiol. 2005 Apr;140(4):396-408. doi: 10.1016/j.cbpb.2005.02.011. Epub 2005 Apr 14.
Ghrelin was originally purified and characterized in rats and humans as the first identified endogenous ligand of the growth hormone secretagogue receptor. In mammals, ghrelin is mainly produced in the stomach, with minor levels of ghrelin present in the brain and various other tissues. Ghrelin is involved in the regulation of many physiological functions including the regulation of growth hormone secretion and food intake in mammals. The gene and peptide structures of ghrelin have been recently identified in several fish species. As in mammals, ghrelin mRNA is mainly expressed in the gut of fish. Ghrelin is involved in the regulation of a number of physiological functions, including the regulation of pituitary hormone release and the stimulation of food intake in fish. In this review, we wish to provide an up-to-date discussion on the structure, distribution and functions of ghrelin in fish, in comparison to ghrelin in other vertebrates.
胃饥饿素最初是在大鼠和人类中被纯化和鉴定出来的，是第一个被确定的生长激素促分泌素受体的内源性配体。在哺乳动物中，胃饥饿素主要在胃中产生，在大脑和其他各种组织中也有少量存在。胃饥饿素参与多种生理功能的调节，包括调节哺乳动物的生长激素分泌和食物摄入。最近在几种鱼类中也鉴定出了胃饥饿素的基因和肽结构。与哺乳动物一样，胃饥饿素mRNA主要在鱼的肠道中表达。胃饥饿素参与多种生理功能的调节，包括调节鱼类垂体激素的释放和刺激食物摄入。在这篇综述中，我们希望就鱼类中胃饥饿素的结构、分布和功能与其他脊椎动物中的胃饥饿素进行比较，提供最新的讨论。
