Hosoda Hiroshi, Kojima Masayasu, Kangawa Kenji
Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan.
Mol Interv. 2002 Dec;2(8):494-503. doi: 10.1124/mi.2.8.494.
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach and is released in response to acute and chronic changes in nutritional state. In addition to having a powerful effect on the secretion of growth hormone, ghrelin stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. Thus, it is interesting to note that the stomach may play an important role in not only digestion but also pituitary growth hormone release and central feeding regulation. We summarize recent findings on the integration of ghrelin into neuroendocrine networks that regulate food intake and energy balance.
胃饥饿素是生长激素促分泌素受体的内源性配体，主要在胃中合成，并根据营养状态的急性和慢性变化而释放。胃饥饿素除了对生长激素的分泌有强大作用外，还能刺激食物摄入，并向下丘脑调节核传导信号以控制能量平衡。因此，值得注意的是，胃不仅可能在消化中发挥重要作用，还可能在垂体生长激素释放和中枢进食调节中发挥重要作用。我们总结了关于胃饥饿素融入调节食物摄入和能量平衡的神经内分泌网络的最新研究结果。
