Mahoney Megan M, Smale Laura
Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109-1109, USA.
Brain Res. 2005 Jul 12;1049(2):156-64. doi: 10.1016/j.brainres.2005.04.071.
Diurnal and nocturnal animals differ with respect to the timing of a host of behavioral and physiological events including those associated with estrus, but the neural bases of these differences have not been elucidated. We investigated this issue by examining the distribution of cells containing gonadotropin-releasing hormone (GnRH) as well as estrogen receptors (ERs) in relation to fibers containing peptides present in the suprachiasmatic nucleus (SCN) in a diurnal animal, Arvicanthis niloticus (the unstriped Nile grass rat). We found that fibers containing two peptides found in SCN cells, arginine vasopressin and vasoactive intestinal polypeptide appeared to be in contact with GnRH and ER positive cells. These data suggest that temporal information is carried along the same direct pathways from the SCN to GnRH and ER neurons in day- and night-active species.
昼行性动物和夜行性动物在一系列行为和生理事件的时间安排上存在差异，包括与发情期相关的事件，但这些差异的神经基础尚未阐明。我们通过研究含促性腺激素释放激素（GnRH）以及雌激素受体（ERs）的细胞分布，与含视交叉上核（SCN）中存在的肽的纤维的关系，来调查这个问题，该研究以昼行性动物尼罗多齿巨鼠（无条纹尼罗河草鼠）为对象。我们发现，含有在SCN细胞中发现的两种肽（精氨酸加压素和血管活性肠肽）的纤维似乎与GnRH和ER阳性细胞接触。这些数据表明，在白天和夜间活动的物种中，时间信息沿着从SCN到GnRH和ER神经元的相同直接途径传递。
