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产前接触甲基苯丙胺会改变在位置导航任务中的学习,而不是新学习任务中的学习。

Learning in the Place navigation task, not the New-learning task, is altered by prenatal methamphetamine exposure.

作者信息

Slamberová Romana, Pometlová Marie, Syllabová Lýdia, Mancusková Magdaléna

机构信息

Department of Normal, Pathological and Clinical Physiology, 3rd Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00 Praha 2, Prague, Czech Republic.

出版信息

Brain Res Dev Brain Res. 2005 Jun 30;157(2):217-9. doi: 10.1016/j.devbrainres.2005.04.005.

Abstract

Adult rats (prenatally methamphetamine-exposed, saline-exposed and controls) were tested for learning in the Morris water maze. Rats were tested in 4 consecutive days using two different types of learning tests: "Place navigation test" (stable platform position) and "New-learning test" (platform position changed daily). Males exposed prenatally to methamphetamine were slower in the Place navigation learning test than were both the control and saline-exposed males. There were no differences in the New-learning test between groups.

摘要

成年大鼠(产前暴露于甲基苯丙胺、生理盐水及作为对照)在莫里斯水迷宫中接受学习测试。使用两种不同类型的学习测试,连续4天对大鼠进行测试:“位置导航测试”(平台位置固定)和“新学习测试”(平台位置每日更换)。产前暴露于甲基苯丙胺的雄性大鼠在位置导航学习测试中的速度比对照组和暴露于生理盐水的雄性大鼠都要慢。各组在新学习测试中没有差异。

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