Caetano Sheila C, Fonseca Manoela, Olvera Rene L, Nicoletti Mark, Hatch John P, Stanley Jeffrey A, Hunter Kristina, Lafer Beny, Pliszka Steven R, Soares Jair C
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Neurosci Lett. 2005 Aug 26;384(3):321-6. doi: 10.1016/j.neulet.2005.04.099.
The dorsolateral prefrontal cortex (DLPFC) plays an essential role in mood regulation and integration of cognitive functions that are abnormal in major depressive disorder (MDD). Few neuroimaging studies have evaluated the still maturing DLPFC in depressed children and adolescents. We conducted single voxel proton magnetic resonance spectroscopy ((1)H MRS) of the left DLPFC in 14 depressed children and adolescents (13.3 +/- 2.3 years old, 10 males) and 22 matched healthy controls (13.6 +/- 2.8 years old, 13 males). Depressed subjects had significantly lower levels of glycerophosphocholine plus phosphocholine (GPC + PC; or choline-containing compounds) and higher myo-inositol levels in the left DLPFC compared to healthy controls. In the depressed subjects, we found significant inverse correlations between glutamate levels and both duration of illness and number of episodes. In healthy controls there was a significant direct correlation between age and glutamine levels, which was not present in the patient group. Lower GPC + PC levels in pediatric MDD may reflect lower cell membrane content per volume in the DLPFC. Increased myo-inositol levels in MDD may represent a disturbed secondary messenger system. GPC + PC and myo-inositol abnormalities further demonstrate the involvement of DLPFC in pediatric MDD.
背外侧前额叶皮质（DLPFC）在情绪调节以及重度抑郁症（MDD）中异常的认知功能整合方面发挥着重要作用。很少有神经影像学研究评估抑郁儿童和青少年中仍在发育的DLPFC。我们对14名抑郁儿童和青少年（13.3±2.3岁，10名男性）和22名匹配的健康对照者（13.6±2.8岁，13名男性）的左侧DLPFC进行了单体素质子磁共振波谱分析（（1）H MRS）。与健康对照者相比，抑郁受试者左侧DLPFC中的甘油磷酸胆碱加磷酸胆碱（GPC+PC；或含胆碱化合物）水平显著降低，而肌醇水平升高。在抑郁受试者中，我们发现谷氨酸水平与病程和发作次数之间存在显著的负相关。在健康对照者中，年龄与谷氨酰胺水平之间存在显著的正相关，而在患者组中不存在这种相关性。小儿MDD中较低的GPC+PC水平可能反映了DLPFC中每单位体积的细胞膜含量较低。MDD中肌醇水平升高可能代表二级信使系统紊乱。GPC+PC和肌醇异常进一步证明了DLPFC参与小儿MDD。
