CD70+抗原呈递细胞控制肠道黏膜中T细胞的增殖和分化。
CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.
作者信息
Laouar Amale, Haridas Viraga, Vargas Dorothy, Zhinan Xia, Chaplin David, van Lier Rene A W, Manjunath N
机构信息
The CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Nat Immunol. 2005 Jul;6(7):698-706. doi: 10.1038/ni1212. Epub 2005 Jun 5.
Abstract
One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.
摘要
肠道免疫中一个尚未解决的问题是黏膜T淋巴细胞如何被激活，以及哪种抗原呈递细胞（APC）对这一过程的调节至关重要。我们已经鉴定出一种独特的APC群体，它们仅存在于固有层中。这些APC组成性地表达共刺激分子CD70，并具有抗原呈递功能。在用单核细胞增生李斯特菌口服感染小鼠后，抗原特异性T细胞在肠道黏膜中发生原位增殖和分化，而阻断CD70共刺激会消除黏膜T细胞的增殖和效应功能。因此，口服感染后肠道黏膜T细胞的增殖和分化需要通过特殊的组织特异性APC进行有效的CD70依赖性刺激。
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