Dean J H, Greene M H, Reimer R R, LeSane F V, McKeen E A, Mulvihill J J, Blattner W A, Herberman R B, Fraumeni J F
J Natl Cancer Inst. 1979 Nov;63(5):1139-45.
Sixty members of 4 families prone to cutaneous malignant melanoma (CMM) and a genetically determined precursor nevus syndrome underwent extensive immunologic evaluation. The most consistent finding was a diminished in vitro response to pooled alloantigens in the one-way mixed leukocyte culture (MLC) and a tendency to low T-lymphocyte and B-lymphocyte levels. When compared to controls, low B-lymphocyte levels and reduced MLC responses were found not only in family members with CMM and/or precursor nevi but also in unaffected blood relatives and spouses. The genesis of the immune dysfunction and its possible relationship to melanoma pathogenesis remain to be clarified.
对4个易患皮肤恶性黑色素瘤（CMM）且患有基因决定的前驱痣综合征的家族中的60名成员进行了广泛的免疫学评估。最一致的发现是单向混合淋巴细胞培养（MLC）中对混合同种异体抗原的体外反应减弱，以及T淋巴细胞和B淋巴细胞水平偏低的趋势。与对照组相比，不仅患有CMM和/或前驱痣的家族成员，而且未受影响的血亲及配偶中均发现B淋巴细胞水平偏低和MLC反应降低。免疫功能障碍的成因及其与黑色素瘤发病机制的可能关系仍有待阐明。
