Santaclara Francisco, Lago Jorge, Vieites Juan M, Cabado Ana G
Microbiology and Biotoxins Area, ANFACO-CECOPESCA, Campus Univ Vigo, 36310 Pontevedra, Spain.
Arch Toxicol. 2005 Oct;79(10):582-6. doi: 10.1007/s00204-005-0679-z. Epub 2005 Jun 4.
Okadaic acid (OA), an algal toxin, is known to induce Diarrhetic Shellfish Poisoning and apoptosis in a variety of cell lines. One of the main targets of OA is the actin cytoskeleton which can be modulated by integrins and other structural proteins. In this paper we studied the role of these proteins and skeletal structures on OA-induced apoptosis in neuroblastoma cells. Results show that beta1 integrin and vinculin are down-regulated when cells were exposed to OA. We observed an interaction between talin and beta1 integrin that is impaired in OA treated cells.
冈田酸（OA）是一种藻毒素，已知会引发腹泻性贝类中毒，并在多种细胞系中诱导细胞凋亡。OA的主要靶标之一是肌动蛋白细胞骨架，它可由整合素和其他结构蛋白调节。在本文中，我们研究了这些蛋白质和骨骼结构在OA诱导的神经母细胞瘤细胞凋亡中的作用。结果表明，当细胞暴露于OA时，β1整合素和纽蛋白会下调。我们观察到在OA处理的细胞中，踝蛋白与β1整合素之间的相互作用受到损害。
