Okada K, Takahashi S, Nagura Y, Hatano M, Shimamura T
2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Nihon Jinzo Gakkai Shi. 1992 Jan;34(1):65-70.
We investigated the early changes of tubules and effect of the oral adsorbent, AST-120, on the early changes of tubules in rats with chronic renal failure. Sprague-Dawley rats were divided into two groups with and without AST-120, after 3/4 nephrectomy. Although there were no significant differences in levels of blood urea nitrogen, serum creatinine, creatinine clearance, inulin clearance, para-aminohippuric acid clearance and urinary N-acetyl-beta-D-glucosaminidase at week 8 between the two groups, the amount of 24-hour urinary protein excretion and the direct systolic blood pressure at week 8 were significantly decreased in the group with AST-120. Examinations by light microscopy at week 8 revealed that proteinaceous casts in the tubules, tubular dilatation and infiltration of monocytes into the interstitium in the group with AST-120 were less prominent than those in the group without AST-120. A significant difference in numbers of proteinaceous casts was noted at week 8 between the two groups. In rats with chronic renal failure at the early stage, it is concluded that the formation of proteinaceous casts, resulting in tubular damage, is increased and that AST-120 delays the occurrence of proteinaceous casts by delaying the increase in urinary protein excretion.
我们研究了肾小管的早期变化以及口服吸附剂AST - 120对慢性肾衰竭大鼠肾小管早期变化的影响。将Sprague - Dawley大鼠在进行3/4肾切除术后分为两组，一组给予AST - 120，另一组不给。虽然两组在第8周时血尿素氮、血清肌酐、肌酐清除率、菊粉清除率、对氨基马尿酸清除率和尿N - 乙酰 - β - D - 氨基葡萄糖苷酶水平上没有显著差异，但给予AST - 120组在第8周时24小时尿蛋白排泄量和直接收缩压显著降低。第8周时的光学显微镜检查显示，给予AST - 120组肾小管内的蛋白管型、肾小管扩张以及单核细胞浸润到间质的情况比未给予AST - 120组要轻。两组在第8周时蛋白管型数量存在显著差异。得出结论，在慢性肾衰竭早期大鼠中，导致肾小管损伤的蛋白管型形成增加，而AST - 120通过延迟尿蛋白排泄增加来延缓蛋白管型的出现。
