Krivolapov Iu A
Arkh Patol. 2005 Mar-Apr;67(2):17-21.
Histopathologic features of immunohistochemically confirmed 37 nodal peripheral T-cell lymphomas are described. Unspecified and 10 angioimmunoblastic T-cell lymphomas were analyzed. The most demonstrative histological features of both types of lymphomas were spectrum of small, medium and large lymphoid cells, lymphoid cells with irregular nuclei, presence of clusters of clear cells, arborizing endothelial venules, increased number of histiocytes, eosinophils and plasma cells. Isolated paracortical expantion, compartmentalization of neoplastic infiltrate and large atypical Reed-Stemberg-like cells were occasional findings. Delineation between peripheral T-cell lymphoma, unspecified and angioimmunoblastic T-cell lymphoma needs evaluation of follicular dendritic cell pattern. The results suggest that detection of histopathologic features typical for peripheral T-cell lymphomas gives an opportunity to compose optimal panel for immunotyping which is absolutely necessary.
本文描述了免疫组化确诊的37例淋巴结外周T细胞淋巴瘤的组织病理学特征。对未分类的以及10例血管免疫母细胞性T细胞淋巴瘤进行了分析。这两种淋巴瘤最具特征性的组织学表现为小、中、大淋巴细胞谱，核不规则的淋巴细胞，透明细胞簇的存在，树枝状内皮小静脉，组织细胞、嗜酸性粒细胞和浆细胞数量增加。孤立的副皮质区扩张、肿瘤浸润的分隔以及大的非典型里德-斯腾伯格样细胞为偶见表现。未分类的外周T细胞淋巴瘤与血管免疫母细胞性T细胞淋巴瘤之间的鉴别需要评估滤泡树突状细胞模式。结果表明，检测外周T细胞淋巴瘤典型的组织病理学特征为组成最佳免疫分型组合提供了机会，而这是绝对必要的。
