Ferrari Franco, Delle Monache Franco, Suárez Alírica I, Arvelo Francisco, Compagnone Reinaldo S
Istituto di Chimica del Riconoscimento Molecolare CNR, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, Italy.
Nat Prod Res. 2005 Jun;19(4):331-5. doi: 10.1080/14786410412331280014.
A new isoflavone 5,7,4'-trihydroxy-3'-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in vitro cytotoxic activity of the new compound 1 was evaluated against cell lines MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon cancer) and human dermis fibroblasts.
从药用面包树的根皮中分离出一种新的异黄酮5,7,4'-三羟基-3'-(3-羟基-3-甲基丁基)异黄酮（水合异威格酮）(1)，以及六种已知的异黄酮2 - 7和(-)-表儿茶素。它们的结构是根据光谱证据确定的。评估了新化合物1对MCF7（人乳腺癌）、PC3（人前列腺癌）、HT29（人结肠癌）细胞系和人真皮成纤维细胞的体外细胞毒性活性。
