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[采用皮内注射乙酰胆碱诱导的汗液反应评估阳痿患者的自主神经功能]

[Assessment of autonomic nervous function in impotence using sweat response induced by intradermal injection of acetylcholine].

作者信息

Tamura M, Furukawa A, Miyamoto T, Kimura K, Kawanishi Y, Numata A, Yuasa M, Imagawa A, Kagawa S

机构信息

Department of Urology, Takamatsu Red Cross Hospital.

出版信息

Nihon Hinyokika Gakkai Zasshi. 1992 Apr;83(4):512-7. doi: 10.5980/jpnjurol1989.83.512.

Abstract

It is important to evaluate the autonomic nervous function which controls penile erection. One method utilizes intradermal injection of acetylcholine to produce localized sweat response. The sweat response depends on the peripheral autonomic nervous supply. Therefore, the response can be used to detect peripheral autonomic nervous dysfunction. We tried to evaluate the peripheral autonomic dysfunction in 29 impotence using a sweat spots test. We classified the 29 impotence into 6 groups with standard tests such as the papaverine test, nocturnal penile tumescence monitoring, recordings of bulbocavernous reflex, etc. The results were as follows: psychogenic IMP; 8, neurogenic IMP; 8, arterial insufficiency; 5, corporeal veno-occlusive insufficiency; 6 neurogenic with arterial insufficiency; 1, and neurogenic with corporeal veno-occlusive insufficiency; 1. The score of sweat spots test was 25.3 +/- 10.9, being in normal, nineteen severe in 3 and slightly abnormal in 7. Many cases of severe and slightly abnormal patients were DM patients classified into neurogenic IMP. We found 2 cases that were not detected by bulbocavernous reflex but found to be abnormal by sweat spots test. Therefore we conclude that this test effective to detect the autonomic nervous dysfunction in impotence.

摘要

评估控制阴茎勃起的自主神经功能很重要。一种方法是利用皮内注射乙酰胆碱来产生局部出汗反应。出汗反应取决于外周自主神经供应。因此,该反应可用于检测外周自主神经功能障碍。我们试图通过汗斑试验评估29例阳痿患者的外周自主神经功能障碍。我们用诸如罂粟碱试验、夜间阴茎勃起监测、球海绵体反射记录等标准测试将29例阳痿患者分为6组。结果如下:心理性阳痿;8例,神经性阳痿;8例,动脉供血不足;5例,海绵体静脉闭塞功能不全;6例,神经性合并动脉供血不足;1例,神经性合并海绵体静脉闭塞功能不全;1例。汗斑试验评分25.3±10.9,正常19例,重度3例,轻度异常7例。重度和轻度异常患者中有许多是归类为神经性阳痿的糖尿病患者。我们发现2例球海绵体反射未检测出异常但汗斑试验显示异常的病例。因此我们得出结论,该试验对检测阳痿患者的自主神经功能障碍有效。

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