Graf J F, Gogolewski R, Leach-Bing N, Sabatini G A, Molento M B, Bordin E L, Arantes G J
Novartis Animal Health, CH-4002 Basel, Switzerland.
Parasitology. 2004;129 Suppl:S427-42. doi: 10.1017/s0031182004006079.
The development of new acaricides is a long and very expensive process. Worryingly, there is increasing resistance to available acaricides worldwide leading to the real possibility that our dwindling supply of effective acaricides will be exhausted unless action is taken to increase the number of new acaricidal products and reduce the rate of resistance development. In 1995, eight major animal health pharmaceutical companies formed the Veterinary Parasite Resistance Group (VPRG) to act as an expert consultative group to guide the FAO in resistance management and collaborate in the prudent use of acaricides. In this paper, members of the VPRG discuss the problems and processes in acaricide development, resistance in the field to commonly used acaricides and the different considerations when targeting the cattle and pet market, and give their view of the future for tick control from the perspective of the animal health industry.
新型杀螨剂的研发是一个漫长且成本高昂的过程。令人担忧的是，全球范围内对现有杀螨剂的耐药性不断增强，这导致一种切实的可能性，即除非采取行动增加新型杀螨产品的数量并降低耐药性发展速度，否则我们日益减少的有效杀螨剂供应将会枯竭。1995年，八家主要的动物保健制药公司成立了兽医寄生虫耐药性小组（VPRG），作为一个专家咨询小组，指导粮农组织进行耐药性管理，并在审慎使用杀螨剂方面开展合作。在本文中，VPRG的成员讨论了杀螨剂研发中的问题和流程、田间对常用杀螨剂的耐药性以及针对牛和宠物市场的不同考量，并从动物保健行业的角度阐述了他们对蜱虫控制未来的看法。
