Serratrice J, Attarian S, Disdier P, Weiller P J, Serratrice G
Timone Hospital, Marseille, France.
Acta Myol. 2004 Dec;23(3):146-50.
Many neurological syndromes associated with antigliadin antibodies have been published. The most frequent are cerebellar ataxia and peripheral neuropathy. Such cases are reported under the title of gluten ataxia or of coeliac neuropathy. However, associations do not prove cause. Herein, a short review is made of the literature and the author's personal experience. Many unsolved questions remain. Gluten sensitivity is probably an immunological response in genetically susceptible individuals with or without enteropathy. Antigliadin antibodies are present in healthy adults, in some idiopathic ataxias and neuropathies. A gluten-free diet is effective on gastrointestinal but not on neurological symptoms. Whether antigliadin antibodies are elevated is more of a waiting classification than a definite diagnosis. Finally, the relationship between antigliadin antibodies and neurological diseases is very weak.
许多与抗麦醇溶蛋白抗体相关的神经综合征已被发表。最常见的是小脑共济失调和周围神经病变。此类病例以麸质共济失调或乳糜泻性神经病变的标题进行报道。然而，相关性并不证明因果关系。在此，对文献和作者个人经验进行简要综述。许多问题仍未解决。麸质敏感性可能是有或无肠病的遗传易感个体的一种免疫反应。抗麦醇溶蛋白抗体存在于健康成年人、一些特发性共济失调和神经病变中。无麸质饮食对胃肠道症状有效，但对神经症状无效。抗麦醇溶蛋白抗体是否升高更多的是一种有待分类的情况，而非明确的诊断。最后，抗麦醇溶蛋白抗体与神经疾病之间的关系非常微弱。
