Banwell Brenda
University of Toronto, Pediatric Multiple Sclerosis Clinic, ON, Canada.
Expert Rev Neurother. 2005 May;5(3):391-401. doi: 10.1586/14737175.5.3.391.
The onset of multiple sclerosis is being increasingly recognized in children and adolescents. There are now approved immunomodulatory therapies for adults with multiple sclerosis. Treatment early in the disease course appears to have a greater impact on disease outcome, an issue of particular importance for children who face decades of multiple sclerosis disease activity. This review summarizes the multiple sclerosis therapies currently available, efficacy data available from studies of these medications in adults and limited information on the use of these medications in children. Future directions in multiple sclerosis therapeutics and specific issues relating to pediatric multiple sclerosis are discussed.
儿童和青少年中多发性硬化症的发病越来越受到关注。目前已有针对成年多发性硬化症患者的获批免疫调节疗法。在疾病病程早期进行治疗似乎对疾病转归有更大影响，这对面临数十年多发性硬化症疾病活动期的儿童来说是一个尤为重要的问题。本综述总结了目前可用的多发性硬化症治疗方法、这些药物在成人研究中的疗效数据以及在儿童中使用这些药物的有限信息。还讨论了多发性硬化症治疗的未来方向以及与儿童多发性硬化症相关的具体问题。
