Patten Scott B
University of Calgary, Department of Community Health Sciences, Alberta, Canada.
Expert Rev Neurother. 2005 May;5(3):413-20. doi: 10.1586/14737175.5.3.413.
The treatment of multiple sclerosis has been revolutionized during the past 10 years by the introduction of disease-modifying therapies. However, day-to-day management of the symptoms and complications of this condition will, for the foreseeable future, continue to be important management concerns. Among the most problematic and troublesome manifestations of multiple sclerosis are its neuropsychiatric manifestations. Most prominent among these are depression, pathologic laughing and crying, fatigue, cognitive problems, sleep disorders and disorders of sexual function. There have been relatively few randomized controlled trials of pharmacologic treatments for these conditions. Available treatments for the management of fatigue and cognitive deficits remain inadequate and patients must often accommodate these symptoms in their lifestyle.
在过去10年中，疾病修正疗法的引入彻底改变了多发性硬化症的治疗方式。然而，在可预见的未来，对该疾病症状和并发症的日常管理仍将是重要的管理关注点。多发性硬化症最具问题性和麻烦的表现之一是其神经精神方面的表现。其中最突出的是抑郁、病理性哭笑、疲劳、认知问题、睡眠障碍和性功能障碍。针对这些病症的药物治疗的随机对照试验相对较少。现有的治疗疲劳和认知缺陷的方法仍然不足，患者常常必须在生活方式中适应这些症状。
