[妊娠期高血压疾病患者血清生物标志物的发现]
[Discovery of biomarkers in the serum from patients with hypertensive disorder complicating pregnancy].
作者信息
Lü Ya-jie, Li Li, Yu Li-li, Xu Yang
机构信息
Department of Obstetrics and Gynecology, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 2005 May;40(5):306-8.
OBJECTIVE
To distinguish patients with hypertensive disorder complicating pregnancy from healthy pregnant women by examining serum protein fingerprinting.
METHODS
Eight patients with hypertensive disorder complicating pregnancy and eight healthy pregnant women were tested by surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS).
RESULTS
At the molecular mass/charge (M/Z) value range from 1300-14,000, the content of three proteins with different M/Z values was obviously different. In spectrometry of patients with hypertensive disorder complicating pregnancy, proteins with M/Z 1325, 13,749 were significantly higher than that in healthy pregnant women (P < 0.05), that with M/Z 3245 was significantly lower than in healthy pregnant women (P < 0.05).
CONCLUSIONS
There is difference in serum protein fingerprinting between healthy pregnant women and patients with hypertensive disorder complicating pregnancy.
目的
通过检测血清蛋白指纹图谱来区分妊娠合并高血压疾病患者与健康孕妇。
方法
采用表面增强激光解吸电离飞行时间质谱（SELDI-TOF-MS）对8例妊娠合并高血压疾病患者和8例健康孕妇进行检测。
结果
在分子量/电荷（M/Z）值为1300 - 14,000的范围内，三种不同M/Z值的蛋白质含量存在明显差异。妊娠合并高血压疾病患者的质谱图中，M/Z为1325、13,749的蛋白质显著高于健康孕妇（P < 0.05），M/Z为3245的蛋白质显著低于健康孕妇（P < 0.05）。
结论
健康孕妇与妊娠合并高血压疾病患者的血清蛋白指纹图谱存在差异。
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