Müller E, Sauter C
Department of Medicine, University Hospital, Zürich, Switzerland.
Leukemia. 1992 May;6(5):419.
To determine whether serial examinations of the peripheral blood can replace regular bone marrow punctures in the diagnosis of a relapse of acute myelogenous leukemia (AML), the peripheral blood of 40 AML patients in remission undergoing regular bone marrow punctures was studied. Within three months prior to bone marrow examination proving relapse in 97% of the relapses, at least one of the following values of the peripheral blood was pathological: blasts (84%), neutrophil granulocytes (72%), thrombocytes (64%), and hemoglobin (58%). The simultaneous appearance of abnormalities in the peripheral blood and the bone marrow occurs in such high incidence that routine bone marrow punctures are rendered obsolete in the follow-up of AML patients. Needless pain and anxiety can therefore be avoided for many AML patients.
为了确定外周血的系列检查能否替代急性髓性白血病（AML）复发诊断中的常规骨髓穿刺，对40例处于缓解期且正在接受常规骨髓穿刺的AML患者的外周血进行了研究。在骨髓检查证实复发的97%的病例中，在复发前三个月内，外周血至少有以下一项指标异常：原始细胞（84%）、中性粒细胞（72%）、血小板（64%）和血红蛋白（58%）。外周血和骨髓同时出现异常的发生率如此之高，以至于在AML患者的随访中常规骨髓穿刺已过时。因此，许多AML患者可以避免不必要的痛苦和焦虑。
