使用汇聚法进行化学文库合成。

Chemical library synthesis using convergent approaches.

作者信息

Beeler Aaron B, Schaus Scott E, Porco John A

机构信息

Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

出版信息

Curr Opin Chem Biol. 2005 Jun;9(3):277-84. doi: 10.1016/j.cbpa.2005.04.005.

DOI:10.1016/j.cbpa.2005.04.005

PMID:15939329

Abstract

New strategies are continuously being developed in combinatorial and diversity-oriented synthesis. Convergent design in target-oriented synthesis is commonly employed for construction of complex molecules. In this mini-review, we describe examples of convergent library design and synthesis as well as potential areas for future development.

摘要

组合化学和导向多样性合成领域不断有新策略被开发出来。在目标导向合成中，收敛式设计常用于构建复杂分子。在本综述中，我们描述了收敛式文库设计与合成的实例以及未来潜在的发展方向。