Spandl Richard J, Díaz-Gavilán Mónica, O'Connell Kieron M G, Thomas Gemma L, Spring David R
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Chem Rec. 2008;8(3):129-42. doi: 10.1002/tcr.20144.
Diversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what can be achieved using the DOS approach to library generation. We describe some of the most successful strategies utilized in DOS, with special focus on our own area of interest; DOS from simple, pluripotent starting materials.
面向多样性的合成(DOS)描述了小分子结构多样集合体的合成,其发展部分是为了弥补组合化学的不足。在本文中,我们希望说明使用DOS方法生成文库能够实现什么。我们描述了DOS中一些最成功的策略,特别关注我们自己感兴趣的领域;从简单的多能起始原料进行DOS。