Zhou Yunhua, Sun Xiaolan, Jin Lei, Stringfield Teresa, Lin Lin, Chen Yan
Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences.
Gene Expr Patterns. 2005 Jun;5(5):711-5. doi: 10.1016/j.modgep.2005.02.002. Epub 2005 Mar 29.
Adiponectin is a protein secreted from adipocytes and it plays an important endocrine role in glucose and lipid homeostasis. A reverse correlation between plasma adiponectin concentrations and insulin resistance has been established in both animals and humans. Adiponectin exerts its function by interacting with membrane receptors, including AdipoR1 and AdipoR2. We investigated the expression pattern of these two adiponectin receptors in mouse embryos. At stages E12.5 and E15.5, both AdipoR1 and AdipoR2 are highly expressed in the nervous system including the trigeminal ganglion, glossopharyngeal ganglion and dorsal root ganglia. AdipoR1 is highly expressed in many tissues derived from primitive gut, including the lung, liver, pancreas and small intestines. Generally, the expression level of AdipoR2 is weaker and more restricted than AdipoR1 in most of the tissues. In addition, AdipoR1 expression can be found in heart, vertebrate, developing bones and cartilage, and many other tissues. This study reveals that AdipoR1 and AdipoR2 have differential but overlapping expression profiles during mouse development.
脂联素是一种由脂肪细胞分泌的蛋白质，在葡萄糖和脂质稳态中发挥重要的内分泌作用。在动物和人类中均已证实血浆脂联素浓度与胰岛素抵抗呈负相关。脂联素通过与膜受体（包括脂联素受体1和脂联素受体2）相互作用发挥其功能。我们研究了这两种脂联素受体在小鼠胚胎中的表达模式。在胚胎第12.5天和第15.5天，脂联素受体1和脂联素受体2在包括三叉神经节、舌咽神经节和背根神经节在内的神经系统中均高度表达。脂联素受体1在许多源自原始肠道的组织中高度表达，包括肺、肝脏、胰腺和小肠。一般来说，在大多数组织中，脂联素受体2的表达水平比脂联素受体1弱且更局限。此外，在心脏、脊椎、发育中的骨骼和软骨以及许多其他组织中均可发现脂联素受体1的表达。这项研究表明，在小鼠发育过程中，脂联素受体1和脂联素受体2具有不同但重叠的表达谱。
