精神分裂症、双相情感障碍患者及其未患病亲属的白质密度。
White matter density in patients with schizophrenia, bipolar disorder and their unaffected relatives.
作者信息
McIntosh Andrew M, Job Dominic E, Moorhead T William J, Harrison Lesley K, Lawrie Stephen M, Johnstone Eve C
机构信息
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK.
出版信息
Biol Psychiatry. 2005 Aug 1;58(3):254-7. doi: 10.1016/j.biopsych.2005.03.044.
BACKGROUND
This study sought to assess white matter density in patients and relatives with histories of bipolar disorder and/or schizophrenia.
METHODS
Subjects included those with schizophrenia from families affected by schizophrenia alone, those with bipolar disorder from families affected by bipolar disorder alone and those with bipolar disorder from families affected by both bipolar disorder and schizophrenia. Unaffected relatives of the three patient groups were also recruited. Subjects underwent an MRI brain scan which was analyzed using a white-matter optimized technique.
RESULTS
Subjects with schizophrenia and bipolar disorder showed reduced white matter density in the anterior limb of the internal capsule which was not found in unaffected relatives. Reductions were found in frontal subgyral white matter density in affected subjects with a family history of schizophrenia only.
CONCLUSIONS
Abnormal anterior internal capsule white matter may provide a structural substrate for both disorders.
背景
本研究旨在评估有双相情感障碍和/或精神分裂症病史的患者及其亲属的白质密度。
方法
研究对象包括仅受精神分裂症影响家庭中的精神分裂症患者、仅受双相情感障碍影响家庭中的双相情感障碍患者以及受双相情感障碍和精神分裂症共同影响家庭中的双相情感障碍患者。还招募了这三组患者的未患病亲属。研究对象接受了脑部磁共振成像扫描，并使用白质优化技术进行分析。
结果
精神分裂症和双相情感障碍患者在内囊前肢的白质密度降低，而未患病亲属未出现这种情况。仅在有精神分裂症家族史的患病受试者中发现额叶脑回下白质密度降低。
结论
内囊前白质异常可能为这两种疾病提供结构基础。
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