Buckingham Steven D, Kidd Jackie F, Law Richard J, Franks Christopher J, Sattelle David B
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
Trends Pharmacol Sci. 2005 Jul;26(7):361-7. doi: 10.1016/j.tips.2005.05.003.
K+ channels that possess two pore domains in each channel subunit are common in many animal tissues. Such channels are generated from large families of subunits and are implicated in several functions, including temperature sensation, responses to ischaemia, K+ homeostasis and setting the resting potential of the cell. Their activity can be modulated by polyunsaturated fatty acids, pH and oxygen, and some are candidate targets of volatile anaesthetics. However, despite their potential as targets for novel drugs for human health, comparatively little is known about the molecular basis of their diverse physiological and pharmacological properties. Genetic model organisms have considerable potential for improving our understanding of these channels. In this article, we review the contributions of some of these genetic model organisms to recent advances in our knowledge of two-pore-domain K+ channels.
每个通道亚基中拥有两个孔结构域的钾离子通道在许多动物组织中都很常见。这类通道由大量亚基家族产生，并涉及多种功能，包括温度感知、对缺血的反应、钾离子稳态以及设定细胞的静息电位。它们的活性可被多不饱和脂肪酸、pH值和氧气调节，并且一些是挥发性麻醉剂的候选靶点。然而，尽管它们有潜力成为人类健康新型药物的靶点，但我们对其多样的生理和药理特性的分子基础了解相对较少。遗传模式生物在增进我们对这些通道的理解方面具有巨大潜力。在本文中，我们回顾了其中一些遗传模式生物对我们在双孔结构域钾离子通道知识方面的最新进展所做的贡献。
