Zinkernagel A S, Speck R F, Ruef C, Zingg W, Berger-Bachi B, Springer B
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Raemistr. 100, 8091 Zurich, Switzerland.
Infection. 2005 Jun;33(3):148-50. doi: 10.1007/s15010-005-4111-7.
A 29-year-old man with rapidly destructive Staphylococcus epidermidis endocarditis after mitral valve reconstruction is presented. Resistance to rifampin and teicoplanin occurred during antibiotic treatment resulting in clinical failure and valve destruction. Subsequently, the patient was successfully treated, by combining valve replacement with antibiotic therapy including quinupristin/dalfopristin, levofloxacin, and vancomycin. In conclusion, S. epidermidis can cause rapid valve destruction with large vegetations, and combination of surgery and antibiotic therapy may be necessary.
本文介绍了一名29岁男性，在二尖瓣重建术后发生了快速破坏性表皮葡萄球菌心内膜炎。抗生素治疗期间出现了对利福平和替考拉宁的耐药性，导致临床治疗失败和瓣膜破坏。随后，通过瓣膜置换联合使用包括奎奴普丁/达福普汀、左氧氟沙星和万古霉素在内的抗生素治疗，患者得以成功治愈。总之，表皮葡萄球菌可导致带有大赘生物的快速瓣膜破坏，手术与抗生素治疗相结合可能是必要的。
