Zabel L T, Worm S
Institut für Laboratoriumsmedizin, Klinik am Eichert, Eichertstr. 3, 73035 Göppingen, Germany.
Infection. 2005 Jun;33(3):155-7. doi: 10.1007/s15010-005-4112-6.
Linezolid, the first of a new class of antibacterial drugs, the oxazolidinones, has inhibitory activity against a broad range of gram-positive aerobic cocci and also against certain anaerobes. Although diarrhea is one of the most frequently encountered adverse effects of linezolid, Clostridium difficile-related complications are very uncommon. One case of fatal C. difficile colitis in a patient with spondylodiscitis, who had received a long-term course of linezolid therapy, is presented. Colitis was able to be exclusively assigned to linezolid. Factors contributing to the colitis are discussed.
利奈唑胺是新型抗菌药物恶唑烷酮类中的首个药物，对多种革兰氏阳性需氧球菌以及某些厌氧菌具有抑制活性。尽管腹泻是利奈唑胺最常出现的不良反应之一，但艰难梭菌相关并发症却非常罕见。本文报告了1例患有脊椎椎间盘炎的患者，在接受长期利奈唑胺治疗后发生致命性艰难梭菌结肠炎的病例。结肠炎能够明确归因于利奈唑胺。文中讨论了导致结肠炎的相关因素。
