Bader Khaldoun A, Schnur Lionel F, Nasereddin Abedelmajeed, Pratlong Francine, Dedet Jean-Pierre, Shaheen Loay, Yousef Obaida, Greenblatt Charles L
Department of Parasitology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Trop Med Int Health. 2005 Jun;10(6):618-20. doi: 10.1111/j.1365-3156.2005.01419.x.
The parasites causing a Palestinian case of infantile visceral leishmaniasis (IVL) and those from four dogs from the Jenin District were identified serologically, biochemically and molecular biologically as Leishmania infantum, showing dogs act as a reservoir. The strain from the human case was distinct because of its unique 200-bp kDNA-polymerase chain reaction (PCR) component in its restriction fragment length polymorphism (RFLP) profile after digestion with the endonuclease RsaI, and by the electrophoretic mobility of its malate dehydrogenase (MDH(140)), designating it the reference strain of a new zymodeme of L. infantum, MON-281.
通过血清学、生物化学和分子生物学方法鉴定出，导致一名巴勒斯坦婴儿患内脏利什曼病（IVL）的寄生虫以及来自杰宁地区四只狗身上的寄生虫均为婴儿利什曼原虫，这表明狗是该寄生虫的储存宿主。该人类病例的菌株具有独特性，在用核酸内切酶RsaI消化后的限制性片段长度多态性（RFLP）图谱中，其独特的200bp kDNA聚合酶链反应（PCR）组分，以及苹果酸脱氢酶（MDH(140)）的电泳迁移率，使其被指定为婴儿利什曼原虫一个新酶带型的参考菌株，即MON-281。
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