Shimabuku Roberto, Ota Arturo, Pereyra Sonia, Véliz Betty, Paz Edith, Nakachi Graciela, More Mario, Oliveros Miguel
Instituto Especializado de Salud del Niño, Lima, Peru.
Biol Neonate. 2005;88(3):168-71. doi: 10.1159/000086206. Epub 2005 Jun 3.
To describe the effect of reoxygenation with 100% O2 as compared to the effect of room air in newborn rat brains after asphyxia.
Experimental asphyxia (carotid artery ligation followed by hypoxic exposure with 8% O2 for 2 h) was performed on 7-day-old rats. After hypoxia-ischemia the rats were reoxygenated with either 100% O2 (hyperoxia group) or 21% O2 (room air group) for 24 h and then returned to the dam. The rats were killed 1 week after the experiment to study the cerebral cortex and hippocampus.
Rats reoxygenated with 100% O2 post-asphyxia showed more frequency of cortical damage (10 of 24 rats) than those reoxy genated with room air (3 of 24 rats) (chi2 test, p = 0.02).
We consider that hyperoxia with 100% oxygen after hypoxia-ischemia can cause more damage in the cerebral cortex than room air in newborn rats.
