Inamori Masahiko, Togawa Jun-Ichi, Iwasaki Tomoyuki, Ozawa Yutaka, Kikuchi Taisuke, Muramatsu Kenichi, Chiguchi Gaku, Matsumoto Shuhei, Kawamura Harunobu, Abe Yasunobu, Kirikoshi Hiroyuki, Kobayashi Noritoshi, Shimamura Takeshi, Kubota Kensuke, Sakaguchi Takashi, Saito Satoru, Ueno Norio, Nakajima Atsushi
Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
J Gastroenterol. 2005 May;40(5):453-8. doi: 10.1007/s00535-005-1569-0.
Medication for the relief of heartburn should have the rapid onset of action required for on-demand use. We studied the inhibition of gastric acid secretion by lafutidine and rabeprazole, given in single doses to fasting and postprandial subjects.
A total of 22 healthy male, Helicobacter pylori-negative volunteers participated in this randomized, two-way crossover study. They were randomly assigned to receive a single oral dose of 10 mg lafutidine or 20 mg rabeprazole after fasting overnight (12 subjects, fasting study) or after eating a test meal (noodles, 364 kcal; protein, 10.1 g; fat, 16 g; carbohydrates, 44.9 g; NaCl, 1.1 g; 10 subjects, postprandial study). Intragastric pH was monitored continuously for 6 h after treatment. The other drug was given after a washout period of at least 7 days, and intragastric pH was similarly monitored.
In the fasting study, lafutidine sustained pH at >3 and >4 during the second, third, fourth, fifth, and sixth hours of the study for significantly longer than rabeprazole. During the first 6 h after treatment, lafutidine sustained pH at more than 2, 3, 3.5, 4, 5, 6, and 7 longer than rabeprazole. In the postprandial study, lafutidine sustained pH >3 and >4 for longer periods than rabeprazole during the third, fourth, fifth, and sixth hours of the study. During the first 6 h after treatment, lafutidine sustained pH at more than 2, 3, 3.5, 4, 5, 6, and 7 longer than rabeprazole.
Lafutidine 10 mg produces a prompter rise in intragastric pH than rabeprazole 20 mg in fasting and postprandial Helicobacter pylori-negative male subjects.
用于缓解烧心的药物应具有按需使用所需的快速起效作用。我们研究了法莫替丁和雷贝拉唑对空腹及餐后受试者胃酸分泌的抑制作用，给予单剂量药物。
总共22名幽门螺杆菌阴性的健康男性志愿者参与了这项随机、双向交叉研究。他们被随机分配在空腹过夜后（12名受试者，空腹研究）或进食试验餐（面条，364千卡；蛋白质，10.1克；脂肪，16克；碳水化合物，44.9克；氯化钠，1.1克；10名受试者，餐后研究）后接受10毫克法莫替丁或20毫克雷贝拉唑的单次口服剂量。治疗后连续6小时监测胃内pH值。在至少7天的洗脱期后给予另一种药物，并同样监测胃内pH值。
在空腹研究中，法莫替丁在研究的第二、第三、第四、第五和第六小时将pH值维持在>3和>4的时间明显长于雷贝拉唑。在治疗后的前6小时内，法莫替丁将pH值维持在高于2、3、3.5、4、5、6和7的时间比雷贝拉唑更长。在餐后研究中，法莫替丁在研究的第三、第四、第五和第六小时将pH值维持在>3和>4的时间比雷贝拉唑更长。在治疗后的前6小时内，法莫替丁将pH值维持在高于2、3、3.5、4、5、6和7的时间比雷贝拉唑更长。
在空腹及餐后幽门螺杆菌阴性的男性受试者中，10毫克法莫替丁比20毫克雷贝拉唑能使胃内pH值更快升高。
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