抗凝蛋白C途径。
The anticoagulant protein C pathway.
作者信息
Dahlbäck Björn, Villoutreix Bruno O
机构信息
Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg laboratory, University Hospital, Malmö, SE-205 02 Malmö, Sweden.
出版信息
FEBS Lett. 2005 Jun 13;579(15):3310-6. doi: 10.1016/j.febslet.2005.03.001. Epub 2005 Mar 13.
The anticoagulant protein C system regulates the activity of coagulation factors VIIIa and Va, cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on endothelium by the thrombin-thrombomodulin-EPCR (endothelial protein C receptor) complex. Activated protein C (APC)-mediated cleavages of factors VIIIa and Va occur on negatively charged phospholipid membranes and involve protein cofactors, protein S and factor V. APC also has anti-inflammatory and anti-apoptotic activities that involve binding of APC to EPCR and cleavage of PAR-1 (protease-activated receptor-1). Genetic defects affecting the protein C system are the most common risk factors of venous thrombosis. The protein C system contains multi-domain proteins, the molecular recognition of which will be reviewed.
抗凝蛋白C系统调节凝血因子VIIIa和Va的活性，它们分别是因子X和凝血酶原激活过程中的辅因子。蛋白C在内皮细胞上被凝血酶-血栓调节蛋白-EPCR（内皮蛋白C受体）复合物激活。活化蛋白C（APC）介导的因子VIIIa和Va的裂解发生在带负电荷的磷脂膜上，且涉及蛋白辅因子、蛋白S和因子V。APC还具有抗炎和抗凋亡活性，这涉及APC与EPCR的结合以及PAR-1（蛋白酶激活受体-1）的裂解。影响蛋白C系统的遗传缺陷是静脉血栓形成最常见的危险因素。蛋白C系统包含多结构域蛋白，本文将对其分子识别进行综述。
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