Wingen Chantal B M, Pauwels Patrick A A, Debiec-Rychter Maria, van Gemert Wim G, Vos M Caroline
Department of Obstetrics and Gynaecology, University Hospital Maastricht, P. Debeyelaan 25, 6229 HX Maastricht, The Netherlands.
Gynecol Oncol. 2005 Jun;97(3):970-2. doi: 10.1016/j.ygyno.2005.01.053.
Gastrointestinal stromal tumours (GIST) are mesenchymal tumours which mostly arise in the gastrointestinal tract showing positive CD117 immunohistochemical staining. In recent years, other locations such as the mesentery and the retroperitoneum have been reported.
A 77-year-old woman presented with a pelvic mass, raising the suspicion of an ovarian or a uterine tumour. During laparotomy, a ruptured process arising from the uterus was seen and removed. Histologic features, immunophenotype and genotype of the tumour supported the diagnosis of a GIST.
To the best of our knowledge, this is the first case of a primary GIST presenting as a uterine mass. Because of recent advances in GIST-therapy, making a correct diagnosis has major clinical implications.
胃肠道间质瘤（GIST）是一种间叶组织肿瘤，大多起源于胃肠道，免疫组化染色显示CD117呈阳性。近年来，已有报道称其可发生于其他部位，如肠系膜和腹膜后。
一名77岁女性因盆腔肿块就诊，怀疑为卵巢或子宫肿瘤。剖腹手术时，发现一个源于子宫的破裂肿物并将其切除。肿瘤的组织学特征、免疫表型和基因型支持胃肠道间质瘤的诊断。
据我们所知，这是首例以子宫肿块形式出现的原发性胃肠道间质瘤。由于胃肠道间质瘤治疗方面的最新进展，做出正确诊断具有重大临床意义。
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