Sparre T, Ejrnaes Sprinkel A M, Bjerre Christensen U, Karlsen A E, Pociot F, Nerup J
Steno Diabetes Center, Gentofte, Denmark.
Acta Diabetol. 2005 Jun;42(2):95-8. doi: 10.1007/s00592-005-0185-z.
Type 1 diabetes (T1D) is an autoimmune disease in genetically predisposed individuals characterised by selective destruction of the beta-cells. Development of diabetes is in the asymptomatic pre-diabetic period characterised by impaired first-phase insulin response and the first clinical symptom is elevated blood glucose (BG). It is still uncertain whether stress or incidental hyperglycaemia can be regarded as predictors for development of T1D or not, even when immunologic and genetic markers for T1D are considered. The aim of this study was to investigate if there was any relationship between elevated BG in 30-day-old anaesthetised pre-diabetic diabetes-prone Bio Breeding (BB-DP) rats and later development of diabetes. Rats anaesthetised by intraperitoneal (ip) injection for islet transplantation displayed significantly higher BG values (Delta1.27 mmol/l, p=8.27x10(-12)) compared to non-anaesthetised non-transplanted rats, indicating that ip injection and/or anaesthesia induce a higher BG level. Linear regression analysis of BG and time of onset of diabetes in transplanted and non-transplanted BB-DP rats revealed no correlation (R(2) at 0.0075 and 0.0324 and p-values at 0.56 and 0.23 respectively). We were not able to identify any association or correlation between the induced temporary hyperglycaemia in 30-day-old BB-DP rats and later development of diabetes.
1型糖尿病（T1D）是一种发生在具有遗传易感性个体中的自身免疫性疾病，其特征是β细胞被选择性破坏。糖尿病的发展处于无症状的糖尿病前期，其特征是第一阶段胰岛素反应受损，而第一个临床症状是血糖（BG）升高。即使考虑了T1D的免疫和遗传标记，应激或偶发性高血糖是否可被视为T1D发展的预测因素仍不确定。本研究的目的是调查30日龄麻醉的糖尿病前期糖尿病易感性生物繁殖（BB-DP）大鼠的血糖升高与糖尿病后期发展之间是否存在任何关系。与未麻醉、未移植的大鼠相比，通过腹腔内（ip）注射进行胰岛移植麻醉的大鼠显示出显著更高的血糖值（Δ1.27 mmol/l，p = 8.27×10⁻¹²），表明ip注射和/或麻醉会导致更高的血糖水平。对移植和未移植的BB-DP大鼠的血糖和糖尿病发病时间进行线性回归分析，结果显示无相关性（R²分别为0.0075和0.0324，p值分别为0.56和0.23）。我们无法确定30日龄BB-DP大鼠诱导的暂时性高血糖与糖尿病后期发展之间存在任何关联或相关性。
