Brunner C, Müller B, Wirth T
Department of Physiological Chemistry, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.
Histol Histopathol. 2005 Jul;20(3):945-55. doi: 10.14670/HH-20.945.
Btk is a cytoplasmic tyrosine kinase, which is mainly involved in B cell receptor signalling. Gene targeting experiments revealed that Btk is important for B cell development and function. However, Btk is not only expressed in B cells, but also in most other haematopoietic lineages except for T cells and plasma cells. Recently we found that Btk is involved in Toll-like receptor signalling. Toll-like receptors play an important role in innate immunity. They are highly expressed on mast cells, macrophages and dendritic cells, which are essential for the recognition and consequently for the elimination of microbial pathogens. Therefore Btk might play an important role for the function of immunocompetent cells of innate as well as adaptive immunity.
布鲁顿酪氨酸激酶（Btk）是一种细胞质酪氨酸激酶，主要参与B细胞受体信号传导。基因靶向实验表明，Btk对B细胞的发育和功能至关重要。然而，Btk不仅在B细胞中表达，在除T细胞和浆细胞外的大多数其他造血谱系中也有表达。最近我们发现，Btk参与Toll样受体信号传导。Toll样受体在固有免疫中起重要作用。它们在肥大细胞、巨噬细胞和树突状细胞上高度表达，这些细胞对于识别并进而清除微生物病原体至关重要。因此，Btk可能在固有免疫和适应性免疫的免疫活性细胞功能中发挥重要作用。
