人胃癌中表皮生长因子受体的酪氨酸激酶活性

Tyrosine kinase activity of epidermal growth factor receptor in human gastric carcinomas.

作者信息

Kameda T, Yasui W, Tsujino T, Nakayama H, Ayhan A, Ito H, Tahara E

机构信息

First Department of Pathology, Hiroshima University School of Medicine, Japan.

出版信息

Pathol Res Pract. 1992 Feb;188(1-2):37-43. doi: 10.1016/S0344-0338(11)81153-2.

DOI:10.1016/S0344-0338(11)81153-2

PMID:1594497

Abstract

We examined tyrosine kinase activity of epidermal growth factor (EGF) receptor in a total of 34 human gastric carcinomas as well as in non-neoplastic gastric mucosa from the same patients. EGF receptor kinase activity of the carcinoma tissues and the non-neoplastic mucosa were 1.28 +/- 1.00 (Mean +/- S.E.) and 0.16 +/- 0.04 respectively, if the EGF receptor kinase activity of human placenta is 10. Twenty-one (62%) carcinoma tissues showed higher EGF receptor kinase activity than corresponding non-neoplastic mucosa, while in 6 cases (18%) the kinase activity was higher in the non-neoplastic mucosa than in the tumor tissues. No obvious correlation was observed between the increased kinase activity in the tumors and histological type or tumor staging. One tumor showed extremely high receptor kinase activity with ERBB gene amplification. This tumor showed strong immunoreactivity to EGF itself.

摘要

我们检测了34例人类胃癌组织以及同一患者的非肿瘤性胃黏膜中表皮生长因子（EGF）受体的酪氨酸激酶活性。若将人胎盘的EGF受体激酶活性设定为10，则癌组织和非肿瘤性黏膜的EGF受体激酶活性分别为1.28±1.00（平均值±标准误）和0.16±0.04。21例（62%）癌组织的EGF受体激酶活性高于相应的非肿瘤性黏膜，而6例（18%）非肿瘤性黏膜的激酶活性高于肿瘤组织。肿瘤中激酶活性增加与组织学类型或肿瘤分期之间未观察到明显相关性。1例肿瘤显示出极高的受体激酶活性并伴有ERBB基因扩增。该肿瘤对EGF本身表现出强烈的免疫反应性。